产品参数

产品概述

产品基本信息

产品名称：2',3'-cGAMP 马来酰亚胺

储存条件：-15℃避光防潮

保质期：12个月

产品物理化学光谱特性

分子量：1156.10

外观：固体

溶剂：DMSO

激发波长(nm)：NA

发射波长(nm)：NA

产品介绍

2',3'-cGAMP 马来酰亚胺是一种出色的试剂，可将 2',3'-cGAMP 共价结合到含硫醇或硫醇修饰的生物靶标，例如蛋白质、肽和核酸。 2',3'-cGAMP 近年来因其作为癌症和病毒感染等靶点的潜力而受到广泛关注。它已被证明可以免疫系统并增强免疫检查点抑制剂的功效，这是一种癌症免疫疗法。 2',3'-cGAMP（环状 GMP-AMP）是一种环状二核苷酸di二信使分子，在先天免疫系统中起着关重要的作用。它由酶 cGAS（环状 GMP-AMP 合酶）合成，以响应从受损或感染细胞中释放的胞质 DNA。一旦合成，2',3'-cGAMP 就会与衔接蛋白 STING（干扰素基因刺激物）结合并触发下游信号通路，从而产生 I 型干扰素和其他细胞因子，从而导致针对入侵病原体的免疫反应。

溶解方案(溶剂以说明书为准)

参考文献

cGAS/cGAMP/STING signal propagation in the tumor microenvironment: Key role for myeloid cells in antitumor immunity.
Authors: Mekers, Vera E and Kho, Vera M and Ansems, Marleen and Adema, Gosse J
Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology (2022): 158-167

Novel Poxin Stable cGAMP-Derivatives Are Remarkable STING Agonists.
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Journal: Angewandte Chemie (International ed. in English) (2022): e202207175

Discovery of Non-Nucleotide Small-Molecule STING Agonists via Chemotype Hybridization.
Authors: Cherney, Emily C and Zhang, Liping and Lo, Julian and Huynh, Tram and Wei, Donna and Ahuja, Vijay and Quesnelle, Claude and Schieven, Gary L and Futran, Alan and Locke, Gregory A and Lin, Zeyu and Monereau, Laura and Chaudhry, Charu and Blum, Jordan and Li, Sha and Fereshteh, Mark and Li-Wang, Bifang and Gangwar, Sanjeev and Pan, Chin and Chong, Colin and Zhu, Xiao and Posy, Shana L and Sack, John S and Zhang, Ping and Ruzanov, Max and Harner, Mary and Akhtar, Fahad and Schroeder, Gretchen M and Vite, Gregory and Fink, Brian
Journal: Journal of medicinal chemistry (2022): 3518-3538

Catalytic asymmetric and stereodivergent oligonucleotide synthesis.
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Crystal structures of human ENPP1 in apo and bound forms.
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Nucleic Acid Sensing Machinery: Targeting Innate Immune System for Cancer Therapy.
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Journal: Recent patents on anti-cancer drug discovery (2018): 2-17

Trafficking-Mediated STING Degradation Requires Sorting to Acidified Endolysosomes and Can Be Targeted to Enhance Anti-tumor Response.
Authors: Gonugunta, Vijay K and Sakai, Tomomi and Pokatayev, Vladislav and Yang, Kun and Wu, Jianjun and Dobbs, Nicole and Yan, Nan
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