产品参数

产品概述

产品基本信息

产品名称：2'，3'-cGAMP琥珀酰亚胺基酯

储存条件：-15℃避光防潮

保质期：12个月

产品物理化学光谱特性

分子量：1216.15

外观：固体

溶剂：DMSO

激发波长(nm)：NA

发射波长(nm)：NA

产品介绍

2',3'-cGAMP 琥珀酰亚胺酯是一种出色的试剂，可将 2',3'-cGAMP 共价结合到生物靶标，例如蛋白质、肽和核酸。 2',3'-cGAMP 近年来因其作为癌症和病毒感染等靶点的潜力而受到广泛关注。它已被证明可以免疫系统并增强免疫检查点抑制剂的功效，这是一种癌症免疫疗法。 2',3'-cGAMP（环状 GMP-AMP）是一种环状二核苷酸di二信使分子，在先天免疫系统中起着关重要的作用。它由酶 cGAS（环状 GMP-AMP 合酶）合成，以响应从受损或感染细胞中释放的胞质 DNA。一旦合成，2',3'-cGAMP 就会与衔接蛋白 STING（干扰素基因刺激物）结合并触发下游信号通路，从而产生 I 型干扰素和其他细胞因子，从而导致针对入侵病原体的免疫反应。

溶解方案(溶剂以说明书为准)

参考文献

cGAS-STING Pathway as the Target of Immunotherapy for Lung Cancer.
Authors: Dan, Qinfu and Yang, Yang and Ge, Hong
Journal: Current cancer drug targets (2023): 354-362

Spermidine enhances the efficacy of adjuvant in HBV vaccination in mice.
Authors: Ito, Daisuke and Ito, Hiroyasu and Ando, Tatsuya and Sakai, Yasuhiro and Ideta, Takayasu and Ishii, Ken J and Ishikawa, Tetsuya and Shimizu, Masahito
Journal: Hepatology communications (2023)

Discovery of podofilox as a potent cGAMP-STING signaling enhancer with antitumor activity.
Authors: Zhang, Conggang and Han, Jing and Hu, Shuiqing and Hu, Yawei and Xu, Yifang and Hou, Yanfei and Yang, Yinlong and Su, Huili and Zhang, Zhengyin and Liu, Peng and Sun, Xuxu
Journal: Cancer immunology research (2023)

Immunogenicity of small-cell lung cancer associates with STING pathway activation and is enhanced by ATR and inhibition.
Authors: Li, Xuetao and Li, Yujun and Zhao, Ziwen and Miao, Nabo and Liu, Guorong and Deng, Liaoyuan and Wei, Shuquan and Hou, Jun
Journal: Cancer medicine (2023): 4864-4881

Model for predicting age-dependent safety and immunomodulatory effects of STING ligands in non-human primates.
Authors: Takahama, Shokichi and Ishige, Kazuya and Nogimori, Takuto and Yasutomi, Yasuhiro and Appay, Victor and Yamamoto, Takuya
Journal: Molecular therapy. Methods & clinical development (2023): 99-115