产品参数

产品概述

产品基本信息

产品名称：2'，3'-cGAMP叠氮化物

储存条件：-15℃避光防潮

保质期：12个月

产品物理化学光谱特性

分子量：1144.14

外观：固体

溶剂：DMSO

激发波长(nm)：NA

发射波长(nm)：NA

产品介绍

2'，3'-cGAMP叠氮化物是将2'，3'-cGAMP偶联到炔烃修饰的生物靶标（如蛋白质、肽和核酸）的优良试剂。近年来，2'，3'-cGAMP因其作为癌症和病毒感染等的潜在靶点而备受关注。研究表明，免疫检查点抑制剂是一种癌症免疫疗法。2'，3'-cGAMP（环状GMP-AMP）是一种环状二核苷酸di二信使分子，在先天免疫系统中发挥关键作用。它是由cGAS（环状GMP-AMP合酶）对受损或感染细胞释放的胞质DNA作出反应而合成的。一旦合成，2'，3'-cGAMP与衔接蛋白STING（干扰素基因的刺激因子）结合，并触发下游信号通路，从而产生I型干扰素和其他细胞因子，从而产生对抗入侵病原体的免疫反应。

溶解方案(溶剂以说明书为准)

参考文献

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