奎诺二 酯（Trolox）

• 英文名：

• Trolox；6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic Acid

• 别名：

• 水溶性维生素E 6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic Acid

• CAS号：

• 53188-07-1

• 分子式：

• C14H18O4

• 分子量：

• 250.29

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产品介绍

MSDS与安全信息

质检证书(CoA)

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•  Trolox is an antioxidant derived from water-soluble vitamin E, with oxygen quenching activity. The activity of Trolox ranges between ferulic acid (sc-204753) and p-coumaric acid (sc-215648). Studies show that lipid peroxidation, cytotoxicity, and apoptosis induced by cytochrome P450 2E1 in Hep G2 cells is blocked in the presence of Trolox. It has been observed that Trolox can quench free radicals and inhibit methylmercury (MeHg)-induced reactive oxygen species (ROS) generation in C6 glial cells. In addition, Trolox has demonstrated the ability to reduce cytotoxicity of Microcystis aeruginosa and microcystin-LR in Artemia franciscana nauplii. 
  
  Technical Information
  
  Appearance: White 
  
  Physical State: Solid 
  
  Solubility: Soluble in 100 ethanol (25 mg/ml), methanol, water(slightly), DMSO (20 mg/ml), DMF (20 mg/ml), and PBS( pH7.2) (3 mg/ml). 
  
  Storage: Store at -20° C 
  
  Melting Point: 187-189 °C (lit.) 
  
  Boiling Point: 450.26 °C at 760 mmHg 
  
  
  Density: 1.22 g/cm3 
  
  Refractive Index: n20D 1.57 
  
  IC50: Rattus norvegicus: EC5050 = 77.8 µM; COX2: IC50 = 150 nM (human); HL-60 (Promyeloblast leukemia cells): IC50 = 3.6 µM (human); Bos taurus: IC50 = 5 µM; COX1: IC50 = 130 nM (human); Rattus norvegicus: IC50 = 14 µM; Brain: IC50 = 41.57 µM (Rattus norvegicus); MCF7 (Breast carcinoma cells): IC50 = 1461 µM (human); Radical scavenging activity: IC50 = 10.6 µM